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Products and Contract Services

GPCRFunctional™  Label Free Services


Label free cell based assays provide an especially attractive representation of GPCR drug pharmacology in a biologically-relevant context. Each G protein class has a characteristic kinetic label free response. This allows for GPCR deorphanization studies and for the delineation of multiple signal transduction pathways originating from a single GPCR.

Key applications of the technology are the possibility to quickly:

  • Identify potential off-target effects in the context of the whole cell
  • Uncover new possible targets for your agonist and antagonist compounds
  • Identify precisely your drugs mode(s) of action that second messenger assays may miss (e.g. inverse agonist or partial agonist modes, multiple signaling pathways, etc)
  • Develop more complete drug-target SAR information following GPCR binding studies



GPCRFunctional™  Label Free AD

CDAS is currently developing label-free assays using recombinant GPCR cell lines. All our assays are developed in 384-well plate format to facilitate High Throughput Screening applications.

Custom Assay Development


CDAS can assist you with the development of any GPCR label free assay in the desired conditions of:

  • Cell environment using recombinant cells or native cell background (disease relevant cell lines, primary cells…)
  • GPCR expression: endogenous or overexpression
Timelines for a complete assay development program are typically 2 to 3 weeks.

To learn more about our GPCR label free assays in development, please contact us.

GPCRFunctional™  Label Free HTS

CDAS uses the SRU BIND® Instrument, which is capable of reading 96-, 384-,  and 1536-well plate formats. As such, we can accommodate low, medium, high throughput campaigns facilitating the outsourcing of your primary and secondary campaigns.









  • All assays developed in a 384 plate format
  • Easily adaptable to HTS conditions
  • A dedicated platform for compound library screening
  • Storage of very large collections of compounds
  • Multi-year expertise in drug screening with flexible customized screening conditions

Technology Platform

  The key features and benefits of the SRU BIND® label-free technology include:

  • No dye is added to ligands or antibodies, greatly reduces artifacts and false results
  • Measures the holistic cellular morphological response rather than a single element (Ca, cAMP, etc)
  • Can detect multiple signaling pathways
  • Is compatible with recombinant or endogenous receptor expression, including primary cells
  • Is compatible with adherent or suspension cells
  • A “universal” platform for all GPCR types

For more information on our Label Free services, please contact us.