LabChip® 3000

ATTENTION!   Notice to LabChip 3000 customers and prospects

LabChip 3000 Users!  New LC3000 Chip Upgrade.  Click here to learn more!

The LabChip 3000 is Caliper’s flagship enzymatic drug discovery system utilizing microfluidic technology for kinase and other enzyme screening, profiling, assay development, mechanism of action and lead optimization studies.

The LabChip 3000 drug discovery system miniaturizes, integrates and automates enzymatic and cell-based assays. LabChip assays are separations-based, so the quality of results exceeds what is achievable in homogenous, well-based assays. High Z' values, few false positives, few false negatives and analytical quality reproducibility are the reasons cited for the increasing reliance on the LabChip 3000. No other screening system identifies weak enzyme inhibitors as reproducibly as the LabChip 3000.

Currently, 75% of the top 15 pharmaceutical companies are actively using Caliper systems as key tools in their screening efforts. Companies like Novartis, Johnson & Johnson, Sanofi-Aventis, Merck, Schering-Plough, Amgen, Lilly, Wyeth, and others are discovering the path to more productive screens. The most cited reason for using the Caliper system? Data quality. The number one application on the LabChip 3000 is kinase profiling, due to the high caliber of information that can be gained and the remarkably quick assay development time.

A variety of enzymatic  assays can be performed on a single LabChip 3000 instrument. The assay menu for the LabChip 3000 includes:
• Serine/Threonine Kinases
• Tyrosine Kinases
• Phosphatases
• Proteases
• Lipid-modifying Enzymes
• G-protein coupled receptors (GPCRs)

Applications

• Kinase Screening & Profiling
• OtherEnzyme Screening & Profiling
• Primary Screening
• Secondary and Selectivity Screening
• Assay Development
• Lead Optimization Studies
• Dose Response (IC50) Determinations
• Mechanism of Action Studies 
• Cell-Based Assays

Features

• Precise control of fluid movement
• Direct measurement of  reactants & products
• Rapid assay development
• Superior data quality
• Lower costs & reagent consumption
• Versatile, standardized platform
• Real time kinetics

Demos

Our product can be demonstrated at our facility in Hopkinton, Massachussetts or other Caliper Life Sciences offices worldwide.  Please contact your local Caliper Representative to arrange a demo.

LabChip 3000 Video

Specifications

Power Requirements
120 V AC, 50-60 Hz
Dimensions
Height	69" (176cm)
Width	32.7" (83cm)
Depth	49.2" (125cm)
Net Weight
750 lbs. (340kg)
Part Numbers
P/N 106861
Power Consumption
1200 or 3000 VA (dependent upon configuration)
Plate Formats
96- and 384-well
Excitation/Emission Wavelengths
633 and 685 nm; 488 and 530nm; 355 (optional) and 440nm

Comments

“Finally, the process that we have described reduces both experimentation cost and time while increasing throughput, making possible what–if experiments that, up to now, had been either prohibitively expensive or too complex to perform. This process results in better solutions, decreased development time and increased productivity.”  
Vertex, COG ’09 & ’07 and Anal. Biochem., 2006:  351 p122